The effect of endometrial local injury in increasing pregnancy rate
- Conditions
- Infertility.Female infertility
- Registration Number
- IRCT201302091141N13
- Lead Sponsor
- Royan Institute
- Brief Summary
Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer (IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle. We believe that the injury created causes release of substances which help in implantation.<br /> Study Design and Subjects: This is a randomized control study designed to evaluate the effect of local injury to the endometrium in non-transfer cycle in patients with previous failed IVF (at least =1 cycles have failed). <br /> Patients will be randomly allotted to control and intervention group. The patients in the intervention group Pipelle endometrial sampling 19-21th day (biopsy in luteal) in the cycle prior to IVF transfer cycle.<br /> Outcome Measures: Clinical pregnancy rate, implantation rate and ongoing pregnancy rate.<br />
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 220
Inclusion Criteria: Previous failed In-vitro fertilization embryo transfer cycle (at least =1 cycles have failed); Patients who are good responders and have good quality embryos in the previous attempts; Age of patients up to 40 years.
Those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma; Those with sonographically detected hydrosalpinx; age over than 40 years old; poor responders to ovarian stimulation.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical pregnancy. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Ultrasound visualization of a gestational sac.
- Secondary Outcome Measures
Name Time Method Biochemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: BhCG test.;Implantation. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Number of sacs by Sonography.;Endometrial thickness. Timepoint: Third day. Method of measurement: Sonography.;Early abortion. Timepoint: Week 12. Method of measurement: Sonography.;Late abortion. Timepoint: Week 20. Method of measurement: Sonography.