Embryo Implantation After Induced Endometrial Injury
- Conditions
- Sterility
- Interventions
- Procedure: Scratching
- Registration Number
- NCT01955356
- Lead Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
- Brief Summary
Some studies have revealed that an induced endometrial injury could improve embryo human implantation in patients with implantation failure.
The purpose of this study is to determine whether the induced endometrial injury could be beneficial for regular patients undergoing IVF
- Detailed Description
Endometrial induced injury has been suggested that could improve embryo implantation in cases of patients with recurrent implantation failure. The mechanisms that induce that improvement remain unknown.
We want to analyse if the endometrial induce injury could be useful in cases of standard patients who require assisted reproductive techniques.
For that purpose we will start a randomized controlled trial with the ideal background in implantation in ART, the egg donation programme.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 600
- 19-44 aged women
- 19-29.9 Kg/m2.
- 1st or 2nd fresh embryo transfer ( egg donation).
- 1 or 2 blastocysts available.
- written agreement.
- > or = 6 mms endometrial thickness.
- Premature ovarian failure.
- Endometrial pathology.
- Insufficient endometrial development.
- Hydrosalpinx
- Mullerian malformations.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Scratching Scratching induced endometrial injury
- Primary Outcome Measures
Name Time Method Ongoing implantation rate (OIR) 12 weeks of pregnancy
- Secondary Outcome Measures
Name Time Method Live born rate (LBR) 9 months after embryo transfer
Trial Locations
- Locations (1)
IVI Valencia
🇪🇸Valencia, Spain