Endometrial Local Injury and Implantation Failure

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Procedure: Endometrial Biopsy

• Registration Number: NCT00837733
• Lead Sponsor: Yazd Research & Clinical Center for Infertility

Brief Summary

The purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The results suggest that in vitro fertilization or intracytoplasmic sperm injection after endometrial biopsy increase pregnancy outcome.

Detailed Description

In a randomized control trial study, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group.

The implantation rate was determined as 10.9% in biopsy group compared with 3.38% in controls. Clinical pregnancy rate was significantly higher in case group than controls (27.1% and 8.9% respectively

Study Timeline

• Study Start: 2008-01
• Primary Completion: 2008-11
• Study Completion: 2008-12
• Status Verified: 2009-02
• Study First Submitted: 2009-02-04
• Study First Submitted QC: 2009-02-04
• Last Update Submitted: 2009-02-04
• Study First Posted: 2009-02-05
• Last Update Posted: 2009-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 115

Inclusion Criteria

• women with recurrent implantation failure which was defined as 2-6 cycles unsuccessful of IVF-ET in which more than 10 high grade embryo were transferred

Exclusion Criteria

• age over than 40 years old
• poor responders to ovarian stimulation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Biopsy catheter	Endometrial Biopsy	Biopsy catheter (Pipelle de Cornier, Prodimed, Neuilly-en-Thelle, France

Primary Outcome Measures

Name	Time	Method
Implantation Rate,Chemical pregnancy rate, Clinical pregnancy rate	One year

Trial Locations

Locations (1)

Research and Clinical Center for Infertility; 🇮🇷 Yazd, Iran, Islamic Republic of