Intermittent Theta Burst Stimulation (iTBS) for the Treatment of Negative Symptoms in Schizophrenia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Schizophrenia
- Sponsor
- Hôpital le Vinatier
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Scale for the Assessment of Negative Symptoms (SANS)
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to determine whether the iTBS is an effective treatment of the negative symptoms of schizophrenia.
Detailed Description
This study will evaluate whether the intermittent Theta Burst Stimulation (iTBS), a new high frequency TMS protocol is efficient in the treatment of the Negative Symptoms of schizophrenia. Neuroimaging studies demonstrate that hypoactivity in the left dorsolateral prefrontal cortex (LDLPFC) was associated with negative symptoms. The investigators hypothesize that iTBS applied to LDLPFC will improve negative symptoms and will improve activity of the LDLPFC measured with Magnetic Resonance Spectroscopy (MRS).
Investigators
Dr. E. Poulet
PUPH
Hôpital le Vinatier
Eligibility Criteria
Inclusion Criteria
- •Schizophrenia according to DSM-IV
- •Negative symptoms for at least 6 weeks
- •Medication resistance according to Kane et al., 1988
- •Age between 18 and 50 years old
- •Informed consent
Exclusion Criteria
- •Contraindication to TMS
- •Pregnancy
Outcomes
Primary Outcomes
Scale for the Assessment of Negative Symptoms (SANS)
Time Frame: before, after 2 weeks of treatment, and 3 times follow-up (1, 3 and 6 months)
Secondary Outcomes
- Neurochemical impact of treatment measured by 1H-MRS, DTI and resting MRI(3 times, before treatment, immediatly after treatment and a last evaluation 3 months after)