Effect of µ-opioid receptor (MOR) versus N-methyl-D-aspartate receptor (NMDAR) involvement in ketamine and methadone effects in healthy volunteers with special focus on antinociception, sedation, respiratory depression and pupil constrictio

Withdrawn

• Conditions: acute pijn; nociception; pain

• Registration Number: NL-OMON32932
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

healthy volunteers, aged 18-45 years.

Exclusion Criteria

Obesity (BMI > 35); Presence of medical disease (heart-, lung-, liver-, kidney-, neurologic disease; diabetes m.; pyrosis; diaphragmatic hernia);
Presence of psychiatric disease; History of chronic alcohol or illicit drug use;
Allergy to study medications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Pain measurements,<br /><br>Minute ventilation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>sedation,<br /><br><br /><br>Miosis</p><br>