In the blood sample of the patients planned for nasal septoplasty was evaluated the level of opioid analgesic receptor and the relations between the level of receptor and pain score,

Not Applicable

Completed

• Conditions: patients undergoing septoplasty operation; Anaesthesiology - Pain management

• Registration Number: ACTRN12619001652167
• Lead Sponsor: MUZAFFER GENCER

Brief Summary

As the level of the µ-Opioid receptor (µORs) increased in the study groups, the duration of the second analgesic requirement increased. Patients with a high level of µORs experienced less analgesic need in the post-op period. In this study, we found that the efficacy of opioid analgesic agents was higher and the need for additional analgesics was lower in patients with higher µ-Opioid receptor (µORs) levels. This effect was thought to be increased by antidepressant effect. Opioid analgesics combined with steroids also reduced need for second analgesic agents.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-01-28
• Study Start: 2019-11-26
• Last Update Posted: 10 December 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patients undergoing septoplasty

Exclusion Criteria

Patients with surgical planning except septoplasty

Study & Design

• Study Type: Interventional
• Study Design: Not specified