Genetic Determinants of Opioids Analgesia

Not Applicable

Completed

• Conditions: Nephrolithiasis

• Registration Number: NCT00226564
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

The response to opioids varies greatly among individuals. Some of these variability is accounted for by genetic factors.

The present study was designed to evaluate the possibility that genetic polymorphism in the gene encoding for mu opioid receptor may explain variability in the response to alfentanil during lithotripsy.

Detailed Description

Not available

Study Timeline

• Study Start: 1997-08
• Study First Submitted: 2005-09-12
• Study First Submitted QC: 2005-09-26
• Study First Posted: 2005-09-27
• Status Verified: 2008-10
• Last Update Submitted: 2008-10-28
• Last Update Posted: 2008-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age > 20

Exclusion Criteria

• Regular use of opioid drugs
• Known hypersensitivity to alfentanil

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Total alfentanil dose used during the procedure.
The extent of respiratory depression.

Trial Locations

Locations (1)

Hadassah Medical Organization; 🇮🇱 Jerusalem, Israel