effect of vitamin D and vitamin C in patients with acute respiratory failure

Phase 3

Recruiting

• Registration Number: IRCT20090822002365N29
• Lead Sponsor: Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 August 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

hospitalized patients in the intensive care unit
suffering from acute respiratory failure (PaO2 = 60 mmHg or PaCO2 > 45 mmHg)
not Suffering from a nervous system disease that prevents the patient from being separated from the mechanical ventilation device
not suffering from AIDS
not suffering from Liver failure
not Suffering from kidney diseases including nephrotic syndrome-
not suffering from gout
not being Pregnancy and breastfeeding
Vitamin D level below 50 ng/mL
not suffering from hypercalcemia (total calcium > 10.6 mg/dL)
not Suffering from hyperphosphatemia (> 1.45 mmol/liter)
not suffering from Tuberculosis
not suffering from sarcoidosis
not Passing more than 24 hours from the diagnosis of the disease to the time of entering the study
not participating in other interventional studies in the last 30 days
not consuming vitamin D and vitamin C supplements in the last 30 days

Exclusion Criteria

Death or hospitalization of the patient less than 3 days from the start of the intervention
Unwillingness to continue studying and cooperating in it
developing contraindications for the administration of vitamin D and vitamin C according to the opinion of the attending physician at the time of the study.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interlukin6. Timepoint: The results are evaluated at the beginning of the study and at the end of the 10th da. Method of measurement: The level of interlukin6 in serum is with ELISA method.

Secondary Outcome Measures

Name	Time	Method
The duration of connection to the ventilator. Timepoint: the end of the study. Method of measurement: From the patient's file.;The duration of connection to the ventilator. Timepoint: 28th and 90th day of study. Method of measurement: From the patient's file.