Combined oral iron chelation in thalassemia
Not Applicable
Completed
- Conditions
- Health Condition 1: null- ThalassemiaHealth Condition 2: D569- Thalassemia, unspecified
- Registration Number
- CTRI/2018/02/012134
- Lead Sponsor
- JIPMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 23
Inclusion Criteria
Children of age 2-18 years with thalassemia and serum ferritin >= 1500ng/ml
Exclusion Criteria
Children with
1. Serum creatinine more than two times the upper limit for age
2. Serum aspartate amino transferase and alanine amino transferase more than five times the upper limit for age
3. Children with absolute neutrophil count less than 1500/mm3 and platelets less than 1 lakh/mm3
4. Significant proteinuria defined by protein creatinine ratio more than 0.5
5. Cardiac failure secondary to myocardial iron toxicity
6. Previous history of allergic reaction to deferiprone or deferasirox
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in serum ferritin levelsTimepoint: 1 year
- Secondary Outcome Measures
Name Time Method 1) Change in cardiac iron concentration quantified by MRI <br/ ><br>2) Change in liver iron concentration quantified by MRITimepoint: 1 year