The Effects of Obesity and Periodontitis on Biochemical Parameters in Women Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 71
- 试验地点
- 2
- 主要终点
- Biochemical variables GCF
研究概览
简要总结
The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].
详细描述
It is thought that adipokines may play a role on periodontal disease in obese subjects, periodontal disease may also aggravate the existing systemic disease by changing the inflammatory parameters in the body. The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Being women,
- •Older than 18 yrs old,
- •Not being pregnant,
- •Not being disabled,
- •For study group; being obese, not for healthy group being systemically health and in normal weight
- •Not treated periodontological in the last 6 months
排除标准
- •Younger than 18 yrs old,
- •Smokers who smokes more than 10 cigarettes in a day,
- •Uncontrolled systemic diseases,
- •Having periodontal treatment
- •who needs antibiotic prophylaxis
研究组 & 干预措施
Obese women
Obese women who participated exercise programme.
干预措施: Exercise (Other)
Normal weighted
Normal weighted women with non-periodontitis
结局指标
主要结局
Biochemical variables GCF
时间窗: 12 week
TNF-A, IL-1B,concentrations levels (pg/µl)
次要结局
- Biochemical variables_Saliva(12 week)
- Biochemical variables_Serum(12 week)
研究者
Esra Guzeldemir-Akcakanat
Professor
Kocaeli University