TCTR20190127003
招募中
未知
Effectiveness of 7-day and 14-day high-dose PPI bismuth-containing quadruple therapy with probiotics supplement for Helicobacter pylori eradication: A double blinded-randomized placebo-controlled study
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- Effectiveness of 7-
- 发起方
- Thammasat University
- 入组人数
- 100
- 状态
- 招募中
- 最后更新
- 去年
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •1\.Having abdominal pain which was indicative for assessing with esophagogastroduodenoscopy consistent with The Gastroenterological Association of Thailand(12\) as followed;
- •â€¢Coexisting with dysphagia
- •â€¢Evidence of gastrointestinal blood loss such as previous history of bloody vomiting, melena and iron deficiency anemia
- •â€¢Unexplained weight loss such as unintended weight losing, recent diagnosis of diabetes mellitus or thyrotoxicosis
- •â€¢Persistent vomiting
- •â€¢Age onset of symptoms \> 50 years old without any explainable causes including drugs and food
- •â€¢Progressive or recurrent symptoms after adequate medical treatments
- •2\.Detecting for H. pylori infection with positive urease test and/or pathological findings of H. pylori and/or positive cultures
- •3\.Having written informed consent for all participants.
排除标准
- •1\.Any cases with upper gastrointestinal bleeding
- •2\.Being treated with medications affecting the research outcome, for example, by using antibiotics including amoxicillin, clarithromycin, tetracycline or metronidazole within 1 month before the enrollment
- •3\.Having contraindication to gastric biopsy such as coagulopathy
- •4\.Any history of drug allergy for Tetracycline, Metronidazole, Bismuth, and Dexlansoprazole
- •5\.Receiving proton pump inhibitor or receiving any antibiotics or bismuth within 4 weeks or consumption of probiotic products within 2 weeks.
- •6\.Being pregnant or raising children with breast\-feeding
- •7\.Having history of H. pylori eradication treatment
- •8\.Having severe underlying disease including end\-stage renal disease requiring hemodialysis or peritoneal dialysis (GFR \< 15\), cirrhosis with Child\-Pugh classification grade C, immunocompromised host with AIDS, malignancy and/or bed ridden cerebrovascular disease.
- •9\.Any cases who receiving anticoagulant
- •10\.Having previous gastric surgery
结局指标
主要结局
未指定
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