Comparison Between Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 290
- 试验地点
- 1
- 主要终点
- Levels of Neutrophils to Lymphocytes and Platelets ratio
研究概览
简要总结
This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.
详细描述
Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients.
Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied.
The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 70 years old.
- •Both sexes.
- •Septic patients (under the third international consensus definitions of sepsis and septic shock).
排除标准
- •Pregnancy
- •Malignancy
- •On immunosuppressive therapy
- •Hematological Disorders
- •Major Trauma
- •Major Burns
- •Child-Pugh Class C Liver Cirrhosis
- •On Hemodialysis
结局指标
主要结局
Levels of Neutrophils to Lymphocytes and Platelets ratio
时间窗: 28 days post-procedure
The ratio of neutrophils to Lymphocytes and Platelets in relation to 28-day mortality among septic patients will be recorded.
次要结局
- Procalcitonin (PCT)(28 days post-procedure)
- Total Leukocytic Count (TLC)(28 days post-procedure)
研究者
MICHAEL GAMAL SAMAAN FARAG
Assistant Lecturer of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Egypt.
Ain Shams University