Neutrophils to Lymphocytes and Platelets Ratio, Procalcitonin, and Total Leucocytic Count as Indicators of Prognostic Outcome in Septic Patients in the Intensive Care Unit.

Recruiting

• Conditions: Neutrophils to Lymphocytes; Platelets; Procalcitonin; Total Leucocytic Count; Prognostic Outcome; Septic Patients; Intensive Care Unit

• Registration Number: NCT07200817
• Lead Sponsor: Ain Shams University

Brief Summary

This study aims to compare Neutrophil to Lymphocyte and Platelet Ratio, Procalcitonin, and Total Leucocyte Count as indicators of prognostic outcome in septic patients in the intensive care unit.

Detailed Description

Sepsis affects more than 30 million people annually worldwide and is one of the significant causes of death in critical patients worldwide. Any infected person can potentially develop sepsis, and the incidence of sepsis is as high as 1-2% of all hospitalized patients.

Many potential sepsis biomarkers have been proposed, procalcitonin (PCT) and C-reactive protein (CRP) being the most frequently studied.

The ratio of neutrophils to lymphocytes and platelets (N/LP) is a low-cost measure that can be obtained through routine blood tests and is often used to reflect the body's inflammatory state.

Study Timeline

• Study Start: 2024-09-20
• Status Verified: 2025-09
• Study First Submitted: 2025-09-23
• Study First Submitted QC: 2025-09-23
• Last Update Submitted: 2025-09-23
• Study First Posted: 2025-10-01
• Last Update Posted: 2025-10-01
• Primary Completion: 2026-03-19
• Study Completion: 2026-03-19

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 290

Inclusion Criteria

• Age from 18 to 70 years old.
• Both sexes.
• Septic patients (under the third international consensus definitions of sepsis and septic shock).

Exclusion Criteria

• Pregnancy
• Malignancy
• On immunosuppressive therapy
• Hematological Disorders
• Major Trauma
• Major Burns
• Child-Pugh Class C Liver Cirrhosis
• On Hemodialysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Levels of Neutrophils to Lymphocytes and Platelets ratio	28 days post-procedure	The ratio of neutrophils to Lymphocytes and Platelets in relation to 28-day mortality among septic patients will be recorded.

Secondary Outcome Measures

Name	Time	Method
Procalcitonin (PCT)	28 days post-procedure	Procalcitonin (PCT) in relation to 28day mortality among septic patients will be recorded.
Total Leukocytic Count (TLC)	28 days post-procedure	Total Leukocytic Count (TLC) in relation to 28day mortality among septic patients will be recorded.

Trial Locations

Locations (1)

Ain Shams University; 🇪🇬 Cairo, Egypt