CMR-derived Quantitative Perfusion for Prediction of FFR

Not yet recruiting

• Conditions: Chronic Coronary Syndrome

• Registration Number: NCT07018778
• Lead Sponsor: Kerckhoff Klinik

Brief Summary

Patients will undergo quantitative perfusion assessment in cardiovascular magnetic resonance imaging (dual bolus or dual sequence approach) as well as invasive coronary angiography for assessment of fractional flow reserve (FFR) including assessment of coronary flow reserve (CFR) and microcirculatory resistance (IMR).

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-06
• Study First Submitted: 2025-06-04
• Study First Submitted QC: 2025-06-04
• Last Update Submitted: 2025-06-04
• Study First Posted: 2025-06-12
• Last Update Posted: 2025-06-12
• Study Start: 2025-07-01
• Primary Completion: 2026-06-30
• Study Completion: 2026-09-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• clinical indication for vasodilatator CMR or invasive coronar angiography
• capability to give informed consent

Exclusion Criteria

• general: non-compliance, <18 years of age, pregnancy
• contraindications for CMR (non-CMR compatible device, chronic kidney disease (eGFR <30ml/min), allergies (medications)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantitative Perfusion	assessment of CMR and invasive data within 24hours	Correlation of myocardial blood flow and perfusion reserve in CMR with invasively dervived fractional flow reserve (FFR), coronary flow reserve (CFR) and microcirculatory resistance (IMR)
Dual bolus vs dual sequence	assessment of CMR and invasive data within 24hours	Compare both CMR-derived quantitative perfusion for prediction of FFR/CFR/IMR

Secondary Outcome Measures

Name	Time	Method
Strain	1day	Correlation of segmental perfusion and myocardial strain
Cardiovascular Hospitalisation (CVH)	12 months	CVH within 12 months
Tissue characterisation	1day	Correlation of segmental perfusion and T1/T2/ECV/LGE

Trial Locations

Locations (1)

Kerckhoff Klinik; 🇩🇪 Bad Nauheim, Hesse, Germany