Zoom@SVDs
- Conditions
- Small vessel disease, SVDs, VCI, lacunar infarcts
- Registration Number
- NL-OMON29334
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
•Symptomatic sporadic SVD defined as
oHistory of clinical lacunar stroke in the last 5 years with a corresponding recent small subcortical infarct visible on MRI scan or CT scan* compatible with the clinical syndrome.
Exclusion Criteria
•Inclusion criteria are not met
•Evidence for a monogenic for of SVDs
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary Objective: <br /><br>To assess which measures of microvascular function on 7T MRI are affected in patients with symptomatic SVDs, relative to controls
- Secondary Outcome Measures
Name Time Method Secondary Objective(s): <br /><br>To establish how microvascular function relates to:<br /><br>•parenchymal lesion presence at baseline and lesion progression after 24 months <br /><br>•cognitive function at baseline and cognitive decline after 24 months <br /><br>•blood pressure (BP) and BP variability<br>