Zoom@SVDs: Zooming in at microvascular malfunction in Small Vessel Diseases with 7T MRI

Completed

Conditions: cerebral small vessel disease
10007963
10003216

Registration Number: NL-OMON47570

Lead Sponsor: eurologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

participants must meet all of the following criteria:
-For the patients only: symptomatic SVD defined as history of clinical lacunar
stroke or cognitive impairment due to SVD
-age over 18
-ability to provide informed consent

Exclusion Criteria

-Other major neurological or psychiatric conditions affecting the brain and
interfering with the study design (e.g. multiple sclerosis, epilepsy,
Parkinson*s disease)
-For the controls only: history of symptomatic SVD or pronounced silent SVD on
MRI
-Contraindications for MRI

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Measures of microvascular function at 7T MRI:<br /><br>- Difference in mean velocity and pulsatility index of perforator flow between<br /><br>patients with SVDs and healthy controls.<br /><br>- Difference in time course of the BOLD-fMRI signal to a visual stimulus in<br /><br>different cortical layers between patients with SVDs and healthy controls.<br /><br>- Difference in Cerebrovascular reactivity (CVR) to a hypercapnic stimulus<br /><br>between patients with SVDs and healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Relationship between measures of microvascular function at 7T MRI and:<br /><br>- Severity (total burden) and location of conventional markers of SVD on 3T MRI<br /><br>at baseline and progression of these lesions after 2 years.<br /><br>- Cognitive functioning at baseline and decline in cognitive function after 2<br /><br>years<br /><br>- blood pressure (BP) and BP variability</p><br>