Zoom@SVDS/CADASIL: Zooming in at microvascular malfunction in Small Vessel Disease due to CADASIL with 7T MRI
Completed
- Conditions
- Cerebral small vessel diseases (SVDs) op basis van Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).10007963
- Registration Number
- NL-OMON44218
- Lead Sponsor
- niversitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
* Symptomatic SVD defined as a diagnosis of CADASIL
* Age 18 years or older
* Capacity to give written informed consent
* Independent in activities of daily living (Modified Rankin score * 3)
Exclusion Criteria
* Inclusion criteria are not met
* Unwillingness or inability to give written consent
* Pregnant women, women of childbearing age not taking contraception
* Contraindications to MRI
* Other major neurological or psychiatric conditions affecting the brain and interfering with the study design
* In case of clinical lacunar stroke syndrome other causes of stroke dan small vessel disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Measures of microvascular function at 7T MRI:<br /><br>- Difference in mean velocity and pulsatility index of perforator flow between<br /><br>patients and controls.<br /><br>- Difference in time course of the BOLD-fMRI signal to a visual stimulus in<br /><br>different cortical layers between patients and controls.<br /><br>- Difference in Cerebrovascular reactivity (CVR) to a hypercapnic stimulus<br /><br>between patients and controls.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>