Nasal Intermittent Positive Pressure Ventilation and Mechanical Ventilation With Heliox in Preterm Infants With Respiratory Distress Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- length of ventilation and risk of mechanical ventilation
研究概览
简要总结
Heliox can lower respiratory resistance, improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.
详细描述
Heliox can improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.
Heliox has not been widely used. More studies on the effects and safety of Heliox in addition to NIPPV and mechanical ventilation should be tried.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 28 Weeks 至 37 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gestational age more than 28 weeks and less than 32 weeks
- •Diagnosed as respiratory distress syndrome
- •Need to use NIPPV ventilation
- •No congenital diseases or hereditary diseases
- •With an informed consent form
排除标准
- •With congenital diseases or hereditary diseases
- •Intubated in the delivery room
- •Need surgery
结局指标
主要结局
length of ventilation and risk of mechanical ventilation
时间窗: participants will be followed for the duration of hospital stay, an expected average of 2 weeks
The primary outcome is the length of ventilation and risk of mechanical ventilation of participants.
次要结局
- Transcutaneous blood gas analysis，ventilator parameters and lung inflammation cytokines(participants will be followed for the duration of hospital stay, an expected average of 2 weeks)
研究者
Yuan Shi
Director, Head of Pediatrics, Principal Investigator, Clinical Professor
Third Military Medical University