Heliox in Preterm Infants With Respiratory Distress Syndrome
Not Applicable
Completed
- Conditions
- Respiratory Distress Syndrome
- Interventions
- Other: heliox
- Registration Number
- NCT01759316
- Lead Sponsor
- Third Military Medical University
- Brief Summary
Heliox can lower respiratory resistance, improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.
- Detailed Description
Heliox can improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.
Heliox has not been widely used. More studies on the effects and safety of Heliox in addition to NIPPV and mechanical ventilation should be tried.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- Gestational age more than 28 weeks and less than 32 weeks
- Diagnosed as respiratory distress syndrome
- Need to use NIPPV ventilation
- No congenital diseases or hereditary diseases
- With an informed consent form
Exclusion Criteria
- With congenital diseases or hereditary diseases
- Intubated in the delivery room
- Need surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description heliox heliox Heliox is use in this group Placebo heliox Oxygen is used in this group
- Primary Outcome Measures
Name Time Method length of ventilation and risk of mechanical ventilation participants will be followed for the duration of hospital stay, an expected average of 2 weeks The primary outcome is the length of ventilation and risk of mechanical ventilation of participants.
- Secondary Outcome Measures
Name Time Method Transcutaneous blood gas analysis，ventilator parameters and lung inflammation cytokines participants will be followed for the duration of hospital stay, an expected average of 2 weeks
Trial Locations
- Locations (2)
Daping Hospital
🇨🇳China, Chongqing, China
Daping Hospital and Research Institute of Surgery
🇨🇳Chongqing, China