Comparing long and short duration antibiotics for abdominal infections
- Conditions
- Health Condition 1: null- Complicated Intra-abdominal Infections
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients of complicated intra-abdominal infections (CIAI) who undergo surgical intervention to achieve adequate source control + one or more of the following:
1. Temperature <=36C or >= 38 C
2. WBC count<=4000 or >= 11,000/mm3
3. Gastrointestinal dysfunction due to peritonitis, precluding intake of more than half their normal diet (as an indicator of an ileus)
1. Non-perforate, non-gangrenous appendicitis or cholecystitis
2. Infected necrotizing pancreatitis.
3. Primary spontaneous bacterial peritonitis
4. Infection associated with indwelling peritoneal dialysis catheter
5.High likelihood of death within 72h[ Patients in the post operative period who require two ionotropes to maintain hemodynamic stability and are above the age of 65]
6.Pregnancy
7.Concurrent infection requiring more than five days of antimicrobial therapy or various antimicrobial regimen.
8.Patients undergoing planned re-laparotomy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Surgical-site infection, <br/ ><br>2. Recurrent intra-abdominal infection requiring either surgical or percutaneous re-intervention <br/ ><br>3. 30 day mortality <br/ ><br>between the groups of patients with complicated intra-abdominal infection (CIAI), receiving conventional antimicrobial therapy and short course antimicrobial therapy <br/ ><br>Timepoint: 30 days
- Secondary Outcome Measures
Name Time Method To compare the Antimicrobial-free days at 30 days between the two groups.Timepoint: 30 days;To compare the duration of antimicrobial therapy for index infection between the two groupsTimepoint: 30 days;To compare the rates of individual primary end point components between the two groupsTimepoint: 30 days;To compare the time to the occurrence of the composite primary outcome between the two groupsTimepoint: 30 days