Effects of curcumin on digestive symptoms and intestinal bacteria in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study

Clinical Research Australia0 个研究点目标入组 79 人开始时间: 2019年9月6日最近更新: 2021年10月18日

适应症

试验速览

暂无简介。

•1. Healthy adults (male and female) between 18 and 65
•2. Mild-to-moderate severity gastrointestinal complaints as measured by the Gastrointestinal Symptom Rating Scale (GSRS) (total score between 10 and 29)
•3. Medication-free for at least 3 months. Use of analgesics (once a week) or contraceptive pills are permissible.
•4. Non-smoker
•5. BMI between 20 and 35
•6. No plan to change diet or commence new treatments over study period
•7. Willing to complete an online informed consent form detailing all pertinent aspects of the trial
•8. Willing and able to take prescribed curcumin/placebo capsules for 8 weeks

•1. Alcohol consumption > 14 standard drinks per week
•2. Current or 12-month history of illicit drug abuse
•3. Pregnant women, women who are breastfeeding or women who intended to fall pregnant.
•4. Suffering from medical conditions including but not limited to: gastrointestinal disease, functional gastrointestinal disorder, diabetes, hyper/hypotension, cardiovascular disease, gallbladder disease/gallstones/biliary disease, endocrine disease, psychiatric disorder, and neurological disease (Parkinson’s, Alzheimer’s disease, intracranial haemorrhage, head or brain injury)
•5. Currently taking curcumin supplements
•6. Antibiotic use in the 4-weeks prior to study commencement
•7. Current use of supplements that may affect digestive function, unless been on stable dose over last 60 days before baseline assessment
•8. Currently taking prebiotic or probiotic supplements

发起方

Clinical Research Australia