Value of Renal Vascular Doppler Sonography in Management of Decompensated Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Alterations in the renal arterial resistivity index
研究概览
简要总结
Although the traditional determinant of renal dysfunction in heart failure was suggested as decreased cardiac output and renal hypo perfusion, recent studies have demonstrated the association of persistent systemic venous congestion and kidney dysfunction. Relief of the congestion has demonstrated to improve renal functions in decompensated heart failure. The current trial was set up to investigate the changes of renal venous impedance and renal arteriolar resistivity indices with diuretic therapy, in patients with congestive renal failure. The investigators asked whether measurement of renal venous impedance index or renal arteriolar resistivity index can guide the practice of diuretic therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Decompensated heart failure
- •Elevated serum creatinine levels on admission
排除标准
- •Atrial fibrillation
- •Obstructive uropathy
- •Patients with ascites
- •Patients who exposed the potential nephrotoxic drugs in the previous week (metformin, antibiotics, chemotherapeutics, iodinated contrast agents and non-steroidal anti-inflammatory agents)
- •Patients who needed positive inotropic agents
研究组 & 干预措施
Group 1
Patients with type 1 cardiorenal syndrome who had improvement of renal functions along with diuretic therapy. Intravenous furosemide treatment.
干预措施: intravenous furosemide (Drug)
Group 2
Patients with type 1 cardiorenal syndrome who did not have improvement of renal functions along with diuretic therapy. Intravenous furosemide treatment.
干预措施: intravenous furosemide (Drug)
结局指标
主要结局
Alterations in the renal arterial resistivity index
时间窗: during hospitalization, an expected average of 4 weeks.
Participants will be followed for the duration of hospital stay, an expected average of 4 weeks.
次要结局
- Alterations in the renal venous impedance index(during hospitalization, an expected average of 4 weeks.)