ncovering bone-muscle-fat interaction in patients with type 2 diabetes: effects of acute and chronic exercise

Not Applicable

Recruiting

• Conditions: Type 2 Diabetes; Metabolic and Endocrine - Diabetes; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12623000025639
• Lead Sponsor: Victoria University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-11
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Males and females aged over 18years with type 2 diabetes. Postmenopausal Females will be required to be a minimum of 12 months post menopause.

Exclusion Criteria

Potential participants will be excluded from the study if they:
-have had any fractures in the previous 3 months, or have commenced antiresorptive medication or any other new osteoporotic treatment within the last three months.
-uncontrolled diabetes, HbA1c >10%
-have any blood or marrow disorders
-have any bone malignancies or tumours
-are taking warfarin or vitamin K supplementation or restriction
-have a body mass index equal to or greater than 40kg/m2
-are professionally active (compete at a high level: national or international sporting competitions)
-are a current smoker, or have ceased smoking in the last 12 months
-have begun any new medications, new physical activity or dietary regimens (food intake) in the last 3 months
-are known to have a high blood pressure (more than 160/100 mmHg) or have been diagnosed with chronic heart failure new york heart association class III or IV or coronary artery disease
-are taking hormone replacement therapy (HRT)
-are taking glucocorticoids or other medications that alter bone metabolism

Additional criteria include:
-are unable to give informed consent independently, we will not include any persons who are unable to give independent informed consent for safety reasons, particularly as we take some invasive measures.
-pregnancy, the effects of maximal exercise whilst during pregnancy remain unclear. For safety precautions we will not include pregnant women.
-unable to understand English, this could potentially be a safety concern if unable to communicate during some of the maximal exertion testing visits, and for the acute exercise bout.

Study & Design

• Study Type: Interventional
• Study Design: Not specified