Bariatric surgery, bone marrow fat and bone mineral density
Completed
- Conditions
- Osteoporosis1001329610005959
- Registration Number
- NL-OMON43737
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
* Female sex
* Age: 50 years and older
* Postmenopausal
* Scheduled for Roux-en-Y gastric bypass (RYGB)
* Able to fit on MRI table
Exclusion Criteria
* Contraindications to MRI scanning as determined by a standard checklist
* Use of bone-modifying or adipose tissue-modifying drugs
* Bone / bone marrow diseases
* Diseases or medication known to have an effect on bone marrow fat
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* Vertebral bone marrow fat fraction measured by quantitative chemical shift<br /><br>imaging (QCSI)<br /><br>* Vertebral volumetric bone mineral density measured by quantitative computed<br /><br>tomography (QCT) </p><br>
- Secondary Outcome Measures
Name Time Method <p>* Bone turnover markers (CTx, P1NP, osteocalcin), vitamin D, PTH, calcium,<br /><br>leptine, adiponectine </p><br>