Epidural Block Impairs Hypoxic Pulmonary Vasoconstriction During One-lung Ventilation: an Electrical Impedance Tomography- Based Prospective Observation Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Assess regional distribution of pulmonary perfusion
研究概览
简要总结
Define the effect of epidural block on HPV by EIT.
详细描述
Epidural block may affect the physiological mechanism of hypoxic pulmonary vasoconstriction, which is still poorly understood. Electrical impedance tomography might be helpful in establishing the hypoxemia etiology at bedside via combining regional ventilation and perfusion information.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 - 80 years Existing central venous and arterial access Chest circumference 70 - 150 cm
排除标准
- •Contraindication to central venous injection of 5 % sodium chloride (NaCl)
- •Contraindications of PulmoVista 500:
- •Patients with pacemakers, defibrillators or other electrically active implants Patients with damaged skin or impaired skin contact of the electrodes due to wound dressings Patients where the attachment of the patient belt could pose a risk to the patient, e.g. patients with spinal lesions or fractures Patients with uncontrolled body movements Extremely obese patients (BMI>50) Patients during pregnancy Patients with massive lung edema Use during electricity-based therapies, such as electrosurgery or electrocautery Use in the presence of strong magnetic fields Use in conjunction with other bioimpedance measurement devices
结局指标
主要结局
Assess regional distribution of pulmonary perfusion
时间窗: within 24 hours
To evaluate the effect of epidural block on pulmonary blood flow distribution.
Assess oxygenation status
时间窗: within 24 hours
To evaluate the effect of epidural block by assessing regional distribution of pulmonary perfusion based on indicator dilution and changes at different points in time during varying states of regional ventilation will be evaluated.
次要结局
未报告次要终点
研究者
Ming Zhong
Professor
Shanghai Zhongshan Hospital