Endothelial function in Systemic Lupus Erythematosus and Wegener's granulomatosis: associations with traditional and non-traditional cardiovascular risk factors
- Conditions
- atherosclerosiscardiovascular disease1000381610003216
- Registration Number
- NL-OMON30402
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
SLE patients:
- fulfil the American College of Rheumatology criteria for SLE
- 20-65 years of age;WG patients:
- fulfil the American College of Rheumatology criteria for WG
- 20-65 years of age;Patients with essential hypertension
- blood pressure of 140/90 mmHg or more
- age and sex matched to SLE patients;Healthy controls:
- age and sex matched to SLE patients
Exclusion Criteria
- pregnancy
- diabetes mellitus
- renal impairment
- MI or sepsis in the past three months
- recent surgery
- clinical history of cardiovascular disease
- cardiovascular conditions that can produce altered blood pressure waveforms: arrythmias, valvular heart disease or congestive heart failure;SLE patients:
- Raynaud's phenomenon
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Small Artery Elasticity (SAE), Large Artery Elasticity (LAE), Intima Media<br /><br>Thickness (IMT), EC Activation Markers (TM, sVCAM-1, vWF, homocysteine, oxLDL,<br /><br>hsCRP), Advanced Glycation Endproducts (AGE), Endothelial Progenitor Cells<br /><br>(EPC) </p><br>
- Secondary Outcome Measures
Name Time Method <p>Blood count, ALAT, ASAT, creatinin, cholesterol, triglycerides,<br /><br>HDL-cholesterol, LDL-cholesterol, CRP, blood pressure, pulse rate, BMI,<br /><br>smoking, family history for CVD </p><br>