Increase in the effectiveness of inhaled salbutamol by supportive use of electrical impedance tomography in ventilated patients

Not Applicable

Recruiting

Conditions: mechanical ventilation
J44.1
Chronic obstructive pulmonary disease with acute exacerbation, unspecified

Registration Number: DRKS00014706

Lead Sponsor: niversitätsklinikum Knappschaftskrankenhaus BochumKlinik für Anästhesiologie, Intensivmedizin und Schmerzmedizin

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

ICU patients with a known obstructive pulmonary disease and / or an acute obstructive problem
-Patient care (ward): interdisciplinary, operative, intensive care unit
-Age> 18 years
-Female or Male
- ventilated patients with a Horovitz index <400, and a study-independent medical indication for salbutamol nebulization in obstructive pulmonary disease and / or an acute obstructive disease.
-written consent or positive vote of a independent consultant

Exclusion Criteria

-Intensive patients with no medical indication and / or contraindication for inhaled salbutamol administration
-Age <18 years
-Weight: severe obesity (BMI> 35)
-Pre-existing conditions and operations: patients with chest trauma or surgery (e.g. pneumectomy), or other lung diseases (e.g. ARDS, pneumonia), ECMO therapy, neuromuscular diseases, severe cardiac diseases (eg NYHA III-IV), acute ischemic events, active implants (eg pacemakers, ICD) or thoracic skin lesions and wound dressings
Refusal by patient, legal representative or consultant
Patients with known salbutamol intolerance, existing pregnancy or lactation, long-term ventilation> 14 days, do-not-resuscitate order

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
This study evaluates the change of airway resistance 30 minutes after salbutamol inhalation and prior use of electrical chest impedance tomography (EIT) for optimization of the respirator setting

Secondary Outcome Measures

Name	Time	Method
Before and 30 minutes after salbutamol inhalation:<br>- Changes made in respirator setting under EIT: Pinsp, PEEP, inspiration-expiration-ration, inspiratory time, respiratory rate, ventilation mode)<br>- assessment of changes in tidal volume, alveolar pressures, compliance, arterial oxygen partial pressure (paO2), Horovitz index, arterial carbon dioxide partial pressure (paCO2), peripheral and arterial oxygen saturation, lower and upper inflection point of the pressure-volume curve,<br>- Region of Interest (ROI), end-expiratory trend (deltaEELI)<br><br>30-day mortality<br>mechanical ventilation<br>duration of ICU treatment<br>Hospital treatment period <br>resumption rate on IC