Comparative study to assess the effect of using steroids in early phase of acute lung injury with lowered oxygenation in children versus children with similar lung aliment who did not receive steroids in same early phase.
Not Applicable
- Conditions
- Health Condition 1: J96-J99- Other diseases of the respiratory system
- Registration Number
- CTRI/2018/09/015727
- Lead Sponsor
- Rainbow childrens hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.All children between 1 month to 18 years of age, intubated for acute hypoxemic lung injury qualifying the criteria of pediatric ARDS (mild , moderate or severe) as per the PALICC definition (2016) shall be included in the study.
Exclusion Criteria
1.Children on CPAP/NIV/HFNC.
2.Children already receiving glucocorticoids.
3.Children who have contra-indication for use of steroids (e.g. immunosuppressed, severe burns( >30% Burns), or gastrointestinal bleed within the past 1 month.
4.Parents refusing for steroids.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of oxygenation status trends during the first 5 days( Pao2/fio2, OI, OSI, SF).Timepoint: First 5 days
- Secondary Outcome Measures
Name Time Method 1.Analysis of clinical outcome parameters like duration of mechanical ventilation, ventilator free days, mortality and morbidity. <br/ ><br>2.Ventilator parameters (FiO2, Tidal volume, Compliance, plateau pressure ) <br/ ><br>3.Need of sedation (cumulative dose of sedatives, paralytics). <br/ ><br>Timepoint: Duration of hospital stay