Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)
- Conditions
- Traumatic Intracranial Hemorrhage
- Interventions
- Diagnostic Test: Repeat Thromboelastography with Platelet Mapping
- Registration Number
- NCT06433622
- Lead Sponsor
- Lancaster General Hospital
- Brief Summary
The aim of this study is to see if administering platelets (cells in our blood that stop or prevent bleeding) results in improved platelet function and slows/stops the progression of a head bleed for patients who have a traumatic head bleed and are on antiplatelet therapy (medications that stop blood cells from forming a blood clot) prior to admission.
- Detailed Description
This study aims to determine if platelet function has improved following platelet transfusion by prospectively performing repeat thromboelastographic with platelet mapping (TEG-PM) assays on all patients consented and enrolled in the study. This study will also examine the rate of progression or stability of ICH on repeat head CT following platelet administration and will aid in the determination of a potential association between repeat CT head findings and the repeat TEG-PM results.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 225
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Repeat TEG-PM Repeat Thromboelastography with Platelet Mapping Will receive a repeat TEG-PM after platelet transfusion based on inclusion criteria.
- Primary Outcome Measures
Name Time Method Repeat TEG 1 hour after platelets given Rate of reversed pathway inhibition on repeat thromboelastography with platelet mapping (TEG-PM) when platelets are administered to TICH patients who are on antiplatelet therapy prior to admission.
Repeat Head CT From the time of interventional platelet administration until the time of patient discharge from their index admission, assessed up to 100 weeks. Number of patients with improved platelet function on repeat TEG-PM and stability of TICH on subsequent CT scan.
- Secondary Outcome Measures
Name Time Method Need for Neurosurgical Intervention During index admission for traumatic intracranial hemorrhage (TICH), assessed through study completion, an average of 2 years. Determine the efficacy of platelet transfusion among this patient cohort by measuring need for neurosurgical intervention after second CT scan (ie: the failure of non-operative management)
Discharge Status From the time of interventional platelet administration until the time of patient discharge from their index admission assessed through study completion, an average of 2 years. Determine the efficacy of platelet transfusion among this patient cohort by reviewing discharge status.
Trial Locations
- Locations (1)
Penn Medicine Lancaster General Health
🇺🇸Lancaster, Pennsylvania, United States