Mechanisms of Anaphylaxis

Active, not recruiting

• Conditions: Anaphylaxis; Febrile Transfusion Reaction; Allergy; Transfusion Reaction
• Interventions: Diagnostic Test: Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)

• Registration Number: NCT03182491
• Lead Sponsor: Haukeland University Hospital

Brief Summary

The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome. The study participants are patients with anaphylaxis, patients with mild allergic reactions, and patients with febrile transfusion reactions. The investigators will also include a group of healthy controls.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-28
• Study First Submitted: 2017-06-07
• Study First Submitted QC: 2017-06-07
• Study First Posted: 2017-06-09
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-02
• Last Update Posted: 2022-08-03
• Primary Completion: 2026-10-01
• Study Completion: 2026-10-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

According to the specific cohort:

1. Diagnosis of anaphylaxis
2. Mild allergic reaction
3. Febrile transfusion reaction
4. Healthy, no known allergic disease

Exclusion Criteria

Suspicion or diagnosed sepsis Children

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Mild allergic reactions	Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)	-
Anaphylaxis	Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)	-
Healthy controls	Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)	-
Febrile transfusion reactions	Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)	-

Primary Outcome Measures

Name	Time	Method
Clarify mechanisms for anaphylaxis and establish biomarkers for this syndrome	2 days	Immunological/nonimmunological mechanism

Trial Locations

Locations (1)

Haukeland University Hospital; 🇳🇴 Bergen, Norway