Mean Systemic Filling Pressure Trends in Liver Transplant Recipients

Completed

• Conditions: Liver Transplant; Complications; Hemodynamic Instability; Liver Diseases

• Registration Number: NCT04462874
• Lead Sponsor: Institute of Liver and Biliary Sciences, India

Brief Summary

Patients with end stage liver disease undergoing liver transplantation have varying degrees of intraoperative haemodynamic unstability during various phases of transplantation. It is difficult to determine the cause for hemodynamic instability in these patients and to predict the best treatments. Currently, cardiovascular resuscitation options are triggered by arterial pressure and cardiac output (CO) measures, focusing on the oxygen delivery side of the circulation. The primary determinants of cardiac output reside on the venous side. Veins are 30-50 times more compliant than arteries and contain approximately 75% of the total blood volume. Mean systemic filling pressure provides vital information on this venous side of the circulation. Mean systemic filling pressure , which is defined as the pressure equal to the pressure which would be measured if the heart should suddenly stop pumping and all (arterial and venous) the pressures in the entire circulatory system should be brought to equilibrium instantaneously, is a good, complete and reliable reflection of the total intravascular fluid compartment. We would study the Mean systemic filling pressure in liver transplant recipients and record hemodynamic, respiratory, cardiac and renal function prospectively. Follow up data for 7 days for respiratory, cardiac and renal complications will be collected, along with hospital stay, ICU stay and mortality. The association between Mean systemic filling pressure and these outcomes will be analyzed.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-07-06
• Study First Submitted QC: 2020-07-06
• Study First Posted: 2020-07-08
• Study Start: 2020-07-15
• Primary Completion: 2021-08-15
• Status Verified: 2021-09
• Study Completion: 2021-12-15
• Last Update Submitted: 2022-01-06
• Last Update Posted: 2022-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• all patients undergoing liver transplantation 18-65 years

Exclusion Criteria

• pregnant patients acute liver failure, acute on chronic liver failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mean systemic filling pressures(MSFP)	1 day	MSFP trends during liver transplantation, hourly

Secondary Outcome Measures

Name	Time	Method
28 day mortality	28 days	mortality by all causes till day 28
icu stay	28 days	duration of stay in the intensive care unit

Trial Locations

Locations (1)

Institute of Liver and Biliary Sciences; 🇮🇳 New Delhi, Delhi, India