Effect of luteal phase stimulation with follicular phase stimulation in poor ovarian response
Phase 3
- Conditions
- Poor ovarian response.Ovarian dysfunction
- Registration Number
- IRCT20210405050852N1
- Lead Sponsor
- Avicenna University Jihad Infertility Center Avicenna
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 78
Inclusion Criteria
History of an ovulation stimulation cycle with less than 4 oocytes
AMH<1.1 ng/ml or AFC<5
The total number of motile sperm is at least 15 million
Normal uterus in ultrasound and hysterosalpingography
Regular periods of 21-35 days
Indication for IVF
Ability to participate and collaborate with study protocol
Signature informed consent
Under 40 years
Exclusion Criteria
History of ovarian surgery
History of pelvic cytotoxic radiation exposure due to malignancy
History of recurrent miscarriage
Grade III or IV endometriosis
Concomitant uterine pathology (adenomyosis, submucosal myoma, Asherman syndrome)
Autoimmune disease
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method umber of metaphase II oocyte. Timepoint: End of ovarian stimulation. Method of measurement: Observation of metaphase 2 oocytes extracted by the embryologist.
- Secondary Outcome Measures
Name Time Method Chemical pregnancy rate. Timepoint: 14 days after transfer. Method of measurement: Beta-Human Chorionic Gonadotropin.;Clinical pregnancy. Timepoint: Pregnancy 7th weeks. Method of measurement: Detect of fetal heart beat on ultrasound.;Total number of embryos. Timepoint: After in vitro fertilization. Method of measurement: 18-20 hours after in vitro fertilization.