Cardiac MRI for the Detection of Myocardial Injury Following Acute Kidney Injury

• Conditions: Cardiomyopathies; Cardio-Renal Syndrome; Acute Kidney Injury
• Interventions: Diagnostic Test: Cardiac magnetic resonance scan

• Registration Number: NCT05034588
• Lead Sponsor: University Hospital, Bonn

Brief Summary

The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay by multiparametric cardiac MRI.

Detailed Description

The aim of the study is to demonstrate any differences in myocardial structure and function using multiparametric cardiac MRI in patients after acute kidney injury (Cardiorenal syndrome type 3) and intensive care stay and subsequent convalescence compared to a control group with intensive care stay but without kidney injury. Furthermore, the correlation between clinical disease severity and cardiac involvement will be investigated.

Study Timeline

• Study Start: 2021-04-07
• Study First Submitted: 2021-08-27
• Status Verified: 2021-09
• Study First Submitted QC: 2021-09-02
• Last Update Submitted: 2021-09-02
• Study First Posted: 2021-09-05
• Last Update Posted: 2021-09-05
• Primary Completion: 2022-07-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Intensiv care patients without kidney injury	Cardiac magnetic resonance scan	Patients with condition after intensive care stay and subsequent convalescence (without kidney injury and preexisting underlying cardiac disease or other disease with potential cardiac involvement).
Intensiv care patients after acute kidney injury	Cardiac magnetic resonance scan	Patients with condition after intensive care stay and acute kidney injury and subsequent convalescence (without preexisting underlying cardiac disease or other disease with potential cardiac involvement).

Primary Outcome Measures

Name	Time	Method
Myocardial T1 relaxation time	Measurement will be performed within 2 weeks after MRI scan.	T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].

Secondary Outcome Measures

Name	Time	Method
Myocardial T2 relaxation time	Measurement will be performed within 2 weeks after MRI scan.	T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\].
Myocardial ECV	Measurement will be performed within 2 weeks after MRI scan.	Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\].
Myocardial strain	Measurement will be performed within 2 weeks after MRI scan.	Cardiac magnetic resonance feature-tracking will be used to asses left ventricular longitudinal, circumferential and radial strain.

Trial Locations

Locations (2)

University Hospital Bonn, Department of Anesthesiology and Intensive Care Medicine; 🇩🇪 Bonn, NRW, Germany

University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology; 🇩🇪 Bonn, NRW, Germany