MYOcardial ischemia detection by circulating bioMARKERs: ‘ the MYOMARKER-study’

Recruiting

• Conditions: angina pectoris; myocardial ischemia; suspected coronary artery disease (SCAD)

• Registration Number: NL-OMON21178
• Lead Sponsor: Meander Medical Center Amersfoort

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 1265

Inclusion Criteria

Patients in the cardiology outpatient clinic of the Meander Medical Center Amerfoort being evaluated because of suspected ischemic coronary disease, who will undergo radionuclide myocardial perfusion imaging (rMPI), as indicated by the treating cardiologist.

- Age > 18yr

Exclusion Criteria

- Patients from whom no informed consent is obtained

- Incapacitated adults: language barriers or other obstacles for full understanding of the study objectives

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Parameter; Extracellular vesicle protein- and miRNA-concentration, and gene expression profiles in circulating cells. <br /><br>Endpoint: Objectified ischemic coronary artery disease, determined by radionuclide myocardial perfusion imaging (Rubidium-82). <br>

Secondary Outcome Measures

Name	Time	Method
Follow-up: all-cause mortality, cardiovascular death, non-fatal MI, coronary revascularisation, stroke, and peripheral vascular interventions. <br>