AC/DC Study: Acidification test in patients with Chronic kidney Disease and healthy Controls - AC/DC study

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Patients with CKD:
•- Plasma bicarbonate level < 20.0 mmol/l
•- Serum potassium >5.5 mmol/l
•- Sodium bicarbonate use in the month preceding the study
•- Heart failure (NYHA III or IV)
•- Liver cirrhosis (Child Pugh B or C)
•- Blood pressure >140/90 mmHg despite the use of 3 different anti-hypertensives
•- Kidney transplantation
•- Use of calcineurin inhibitors
•- Known urea cycle disorder
•- Alcoholism or drug use
•- Pregnancy
•- Current use of antibiotics, NSAIDS or alkalizing drugs (sodium-bicarbonate, citric acid, potassium citrate, acetazolamide)
•- Inability to adhere to the study protocol (due to language barrier or intellectual disability);Healthy subjects:
•- eGFR < 90 ml/min/1.73 m2
•- plasma bicarbonate < 20 mmol/l.
•- History of, or drugs for, diabetes mellitus
•- History of chronic diarrheal disease
•- Ileostomy/colostomy
•- Known urea cycle disorder
•- Alcoholism or drug use
•- Pregnancy
•- Current use of antibiotics, antihypertensive drugs, NSAIDS or alkalizing drugs
•- Inability to adhere to the study protocol (due to language barrier or intellectual disability)

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