COMPARISON OF INTRAVENOUS PALONOSETRON, DEXAMETHASONE AND THEIR COMBINATION AS ANTIEMETIC THERAPY IN LAPAROSCOPIC SURGERIES
Not Applicable
- Conditions
- Health Condition 1: null- Adult ASA Grade I or II patients of either sex, aged 18 to 60 years, who underwent elective laparoscopic surgeries undergeneral anaesthesia.
- Registration Number
- CTRI/2016/07/007108
- Lead Sponsor
- Dr Neha Sadhoo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
Adult ASA Grade I or II patients, who underwent elective laparoscopic surgeries under
general anaesthesia.
Exclusion Criteria
1. Pregnant or lactating females
2. Patients older than 60 years or younger than 18 years of age
3. Patients with a history of central nervous system or neuromuscular disease
4. Patients with ASA physical status grade > II
5. Morbidly obese patients
6. Patients with hepatic, renal or cardio-respiratory disease
7. Patients with gastro-esophageal reflux
8. Patients with history of drug or alcohol abuse
9. Patients with known hypersensitivity to either Palonosetron or Dexamethasone
10. Patients with previous history of PONV or motion sickness
11. Patients receiving chemotherapy or radiotherapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Incidence of PONV- using a 3- point scale ( 0-none, 1-nausea, 2- <br/ ><br>vomiting ). <br/ ><br>2. Number of patients needing rescue antiemetic treatment. <br/ ><br>3. Pain intensity scores- obtained with VAS test.Timepoint: 0, l, 2, 4, 8 and <br/ ><br>24 hours
- Secondary Outcome Measures
Name Time Method 1. Heart rate <br/ ><br>2. Blood pressure <br/ ><br>3. Respiratory rate <br/ ><br>4. Incidence of nausea and vomiting <br/ ><br>5. Visual analogue scale scoreTimepoint: 0, l, 2, 4, 8 and <br/ ><br>24 hours