Clinical study of abdominal acupuncture combined with Dachaihu decoction on the protection of intestinal barrier function in patients with sepsis
Phase 1
Recruiting
- Conditions
- Sepsis
- Registration Number
- ITMCTR2100004390
- Lead Sponsor
- Beijing University of Chinese Medicine Shenzhen Hospitai
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
1. Patients meeting the diagnostic criteria of sepsis;
2. Patients with gastrointestinal dysfunction;
3. Patients who meet the diagnostic criteria of Shaoyang Jianli syndrome;
4. Patients aged 18-80 years old;
5. Informed consent signed by patients or their families.
Exclusion Criteria
1. Incomplete observation items, lack of important observation index items, resulting in unable to evaluate the efficacy and safety index;
2. The subjects who used some prohibited drugs or other drugs that affect the efficacy and safety evaluation during the trial.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TCM Syndrome Points;Intestinal flora detection;Gastrointestinal dysfunction score;
- Secondary Outcome Measures
Name Time Method ICU hospital stay;Serum inflammatory factors (TLR-4, NF-kB, IL-6, PCT, CRP);Immunological index (CD4+, CD8+, Treg, Th17, IL-10);28-day mortality;Serological indicators of intestinal mucosal barrier function (I-FABP, ZO-1, Occludin, LPS);APACHE-II??;Marshall??;