To evaluate the effectiveness of intravenous dexmedetomidine infusion on intraoperative hemodynamics during laparoscopic surgery : A prospective randomised study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- Effectiveness of perioperative iv dexmetadomidine on
研究概览
简要总结
This study aims to evaluate the effectiveness of intravenous dexmedetomidine infusion on intraoperative haemodynamics during laparoscopic surgeries. The study will be a prospective, double-blinded, randomized interventional study conducted at Jawaharlal Nehru Medical College and Associated Group of Hospitals, Ajmer.
The study will include 98 patients undergoing laparoscopic surgeries, randomly assigned to either a dexmedetomidine group or a control group. Dexmedetomidine will be administered intravenously as a bolus followed by an infusion, while the control group will receive normal saline.
The primary objective is to assess the impact of dexmedetomidine on haemodynamic parameters during various time intervals throughout the surgery. Secondary objectives include evaluating the drug’s effectiveness in reducing pressor response due to laryngoscopy, facilitating smooth extubation while maintaining haemodynamic stability, and observing any side effects like hypotension, bradycardia, or sedation.
The study’s findings will be analyzed using statistical methods to compare the haemodynamic response, sedation levels, and side effects between the two groups. The results will contribute to understanding the clinical benefits of dexmedetomidine for managing haemodynamic instability during laparoscopic surgeries and improving patient safety and recovery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged 18-60 years of either sex -Body weight 40-80 kilogram -ASA Grade first and second -Patients scheduled for laproscopic surgery and who are willing to give written and informed consent for general anaesthesia.
排除标准
- •Age less then 18 years and more then 60 years
- •ASA grade third and fourth
- •Patients not willing to participate in the study
- •Patients with a history of drug allergy
- •Patients with chronic pre-existing disease like Asthma, Renal or Hepatic dysfunction, diabetes mellitus, neuro muscular diseases, severe respiratory diseases etc.
- •Pregnancy/Lactation.
结局指标
主要结局
Effectiveness of perioperative iv dexmetadomidine on
时间窗: Baseline
haemodynamic
时间窗: Baseline
次要结局
- 1. Pressor response due to laryngoscopy(2. Smooth extubation with maintaing haemodynamic stability)
研究者
Dr Veena Patodi
JLN medical college and hospital