Beneficial Effects of Music on Cognition and Consciousness Level
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 2
- 主要终点
- P300 response in brain-damaged patients
研究概览
简要总结
Exposure to music improves cognitive function in 'healthy' participants and in brain-damaged patients. However, it is still difficult to understand what precisely in music causes a positive effect : are they emotional components, familiarity or preference which improve cognition or is there any specific effect of music? Moreover, it is not yet possible to characterize the neural and functional links between the brain systems solicited by music and those associated with other cognitive functions enhanced by music.
Finally, researches on brain-damaged patients have not exploited the potential effect of music on the level of alert and perceptual awareness, while this type of stimulation could be a valuable tool to improve cognition in patients with a disturbance of consciousness and alertness.
The main objective is to describe the impact of music on the brain's response to self-referential or neutral stimuli in brain-damaged patients with persistent consciousness disorder after a coma and in healthy participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Disorders of consciousness (Traumatic brain injury, stroke or anoxic encephalopathy)
- •Coma diagnosis (Plum and Posner, 1966), vegetative state (Task Force, 1994) or minimally conscious state (Giacino, Ashwal et al. 2002)
- •Lack of autonomic crisis since one week minimum
- •Medical condition considered stable
- •Patients who do not present hearing loss. Peaks I and II of Brainstem Auditory Evoked Potentials (BAEP) will be normal.
排除标准
- •Hearing Problem
- •Uncontrolled Epilepsy
- •Autonomic crises
- •Medical unstable state
- •Pregnant or likely to be (interrogation data) or breastfeeding woman
- •Healthy participants :
- •Inclusion Criteria:
- •Subjects with normal hearing
- •Absence of neurological disorder
- •Subjects able to understand the experimental instructions
- •Exclusion Criteria:
- •Hearing problems and / or hearing loss higher than 30 decibels Hearing Level (dB HL) at a frequency band from 250 to 8000 Hz
- •Neurological disorders
- •Pregnant or likely to be (interrogation data) or breastfeeding woman
结局指标
主要结局
P300 response in brain-damaged patients
时间窗: 24 hours after inclusion
Improvement of the P300 response (increase in amplitude and / or a decrease in latency) to the first name pronunciation will be assessed in patients in coma, in a vegetative state or in a minimally conscious state, when it is preceded by a favorite or familiar sound (music, language, environmental noise) and / or a positive emotional connotation, compared to a control condition (unfamiliar sound and / or neutral emotional connotation). This improvement in brain response will be the sign of a more efficient categorization of patient's own name.
次要结局
- P300 response in brain-damaged patients(24 hours after inclusion)
- Medial prefrontal cortex activity level in healthy volunteers(24 hours after inclusion)
- P300 response in healthy volunteers(24 hours after inclusion)