Intravenous and oral rehydration of children with severe malnutrition and gastroenteritis

Not Applicable

• Conditions: Severe acute malnutrition; Nutritional, Metabolic, Endocrine; Severe acute malnutrition and dehydration due to gastroenteritis

• Registration Number: ISRCTN76149273
• Lead Sponsor: Imperial College, London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-08
• Last Update Posted: 29 April 2024
• Study Completion: 2024-10-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 336

Inclusion Criteria

Severe dehydration - Stratum A:
1. Aged 60 days to 12 years
2. Severe malnutrition defined as any of the following: Mid-upper arm circumference (MUAC) <11.5 cm, weight for height Zscore (< -3SD), or signs of kwashiorkor
3. Gastroenteritis, defined as > 3 loose stools per day
4. Signs of severe dehydration, defined (as per WHO definition) as at least one of the following: unable to drink, Alert Voice Pain Unresponsive scale (AVPU) < A, sunken eyes, reduced skin pinch (>2 seconds) or inability to take or retain oral fluids, and/or shock (defined as patient with cold peripheries, weak and fast pulse and capillary refill time > 3 seconds)

Moderate/some dehydration - Stratum B:
1. Aged 60 days to 12 years
2. Severe acute malnutrition criteria, complicated by dehydrating diarrhoea (defined as > 3 loose stools per day)
3. Some to moderate dehydration or completing management of severe dehydration. Some to moderate dehydration defined as two of the following: restlessness, irritability, thirst, sunken eyes or skin pinch goes back slowly

Exclusion Criteria

1. Diarrhoea lasting more than 14 days
2. Known congenital or rheumatic heart disease
3. Refusal of consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified