The Evaluation of the Effects of the Use of Rocuronium and Sugammadex on Neuromuscular Block in Smoker
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 主要终点
- Neuromuscular block recovery time
研究概览
简要总结
We compared the durations of antagonizing and of the severity of effect of sugammadex used in antagonizing the rocuronium in smoker and non-smoker total 40 patients with using Train of Four(TOF) neuromuscular monitorization.
详细描述
40 patients from American Society of Anesthesiologist (ASA) I- II class, being smokers for at least 10 years or non-smokers, who will undergo elective surgery were included in this randomized prospective study. Patients underwent routine monitoring and neuromuscular monitoring. Propofol 2 mg/kg and intravenous fentanyl 1 mcg/kg were applied at induction. After the loss of eyelash reflex, intravenous rocuronium 0,6 mg/kg was administered. The patient was intubated at a Train of Four count of 2. Anesthesia was continued with 50% O2 + 50% air and sevoflurane 2 % . Rocuronium 0,15 mg/kg was administered when TOF (Train of Four) counter reached 2 during the operation. Sugammadex 2 mg/kg was administered at the end of the operation. The time to reach Train of Four values of 0,7-0,8-0,9 were recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective surgery,
- •1-2 according to the ASA ( American Society of Anesthesiologist ) physical status classification.
- •Patients who have smoked at least 10 packs or have been smoking for 10 years and currently smoking
- •Or never smoked patients
排除标准
- •neuromuscular diseases
- •radiotherapy and/or chemotherapy anamnesis,
- •liver and/or renal disease,
- •electrolyte balance,
- •history of drug use which affects neuromuscular transmission,
- •Body Mass Index (BMI) of more than 27,
- •use alcohol
研究组 & 干预措施
Smokers
The patients who have smoked at least 10 packs or have been smoking for 10 years and currently smoking were included in the smoker group At the end of operation for reversal of neuromuscular blockade sugammadex used.
干预措施: sugammadex (Drug)
Nonsmokers
The patients who never smoked were included in the non-smoker group At the end of operation for reversal of neuromuscular blockade sugammadex used.
干预措施: sugammadex (Drug)
结局指标
主要结局
Neuromuscular block recovery time
时间窗: six months
Time to reach TOF %90 measurement after given neuromuscular blocker reverse agent
次要结局
未报告次要终点