Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects
Not Applicable
Recruiting
- Conditions
- To Investigate Retinal Oxygen Extraction in Different Age Groups of Healthy Individuals
- Interventions
- Registration Number
- NCT06643403
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age related changes in otherwise healthy subjects. In addition, the study will explore short-term changes in retinal metabolism induced by breathing pure oxygen. Measurements will be performed with dynamic vessel analyzer and laser speckle flowgraphy to evaluate retinal blood flow and retinal oxygen saturation, in order to calculate retinal oxygen extraction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Men and women aged between 18 and 80 years
- Signed informed consent
- Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
- Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant for the purpose of the study
- Nonsmokers
Exclusion Criteria
- Abuse of alcoholic beverages or drugs
- Participation in a clinical trial in the 3 weeks preceding the study
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- Blood donation during the previous 3 weeks
- Pregnant or breast-feeding women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Arm 1 Oxygen 100% Gas for Inhalation SAUERSTOFF medizinisch, Messer GmbH, Industriestrasse 5, 2352 Gumpoldskirchen, Austria Dose: min. 95.5%, breathing for max. 45 minutes
- Primary Outcome Measures
Name Time Method Retinal oxygen extraction in different age groups 15 minutes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Clinical Pharmacology, Medical University of Vienna, Austria
🇦🇹Vienna, Austria