Descriptive and Retrospective Analysis of Acute Myocarditis Associated With Pandemic COVID-19 in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- Acute myocarditis
研究概览
简要总结
The study objectives are to descript clinical, biological and echocardiographic features of an acute myocarditis in children in the context of COVID-19 and to identify the underlying mechanism : direct viral damage and/or inadequate host response risk.
详细描述
An unexpected increase of shock with fever in children suspected to be infect by the COVID-19 is observed. These children present with similar symptoms and seem to have similar clinical time course.
This unexpected phenomenon needs to be extensively described in order to further the knowledge of unusual COVID-19 presentation in children.
The study consists an extensive retrospective data collection from April 2020 till the end of the main SARS-Cov-2 outbreak, from medical file of children have exhibited acute myocarditis and cared in 4 pediatric intensive care units of Assistance Publique-Hôpitaux de Paris of Ile-de-France region.
The study objectives are to descript clinical, biological and echocardiographic features of an acute myocarditis in children in the context of COVID-19 and to identify the underlying mechanism : direct viral damage and/or inadequate host response risk.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age < 18 years
- •Admitted to PICU from April 2020
- •Presented with an acute myocarditis, fever and shock with a possible COVID-19 infection
排除标准
- •Age ≥ 18 years
- •Other etiologies of acute myocarditis than the COVID-19
- •Opposition expressed by the holders of parental authority
结局指标
主要结局
Acute myocarditis
时间窗: 7 days
Occurrence, description and time course of acute myocarditis
Multi-systemic inflammatory syndrome
时间窗: 7 days
Occurrence, description and time course of multi-systemic inflammatory syndrome, features of Kawasaki disease
Kawasaki disease
时间窗: 7 days
Occurrence, description and time course of features of Kawasaki disease
次要结局
- Results of SARS-CoV-2(7 days)