Effectiveness of Green tea mouth rinse on radiation-induced mucositis in patients with head and neck cancer
- Conditions
- Radiation induced oral mucositis.Mucositis(oral) (oropharyngeal): NOS
- Registration Number
- IRCT2013090914606N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
patients older than 18 years old; patients that are diagnosed with the head and neck cancer; minimum dose of radiation therapy must be 50Gy to induce mucositis; patients who are able to use mouthwash before radiotherapy session; patients sign informed consent; at least 50% of the oral cavity area should be under radiation fields; having an ideal oral hygiene; absence of active infection in the oral cavity such as HSV, candida and aphthous ulcers. Exclusion criteria: patients currently suffering from any kind of oral diseases, e.g. active oral infection, ulcer, etc.; patients receiving chemotherapy combined with radiotherapy patients that are not able to use mouthwash; patients who have a broad extent of the lesions and grade IV mucositis; patients who use local anesthetic in the study; patients who are not willing to leave their unsafe habits such as smoking, alcohol, spicy and acidic foods; patients with a history of allergy to green tea; patients with lesions in the oral cavity area; patients who recently have used prostaglandin inhibitors, vitamin E and antioxidant supplements; lack of cooperation at every stage of project.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Type of mouthwash for treatment. Timepoint: after the termination of study. Method of measurement: revealing the mouth wash anyone was receiving after the end of study.;Sex. Timepoint: before the beginning of study. Method of measurement: observation.;Weight. Timepoint: At the beginning and end of radiotherapy. Method of measurement: Scaler.;Received radiation dose. Timepoint: The total dose received during the meetings. Method of measurement: Grey.;Age. Timepoint: at the beginning of study. Method of measurement: year.;Name of cancer. Timepoint: Before the beginning of study. Method of measurement: Pathology report.;Cancer location. Timepoint: Before the beginning of study. Method of measurement: Medical records.
- Secondary Outcome Measures
Name Time Method Pain and soreness. Timepoint: Every week. Method of measurement: Visual analogue scale.;Mucositis grading. Timepoint: Every week. Method of measurement: WHO grading(0-4).