The prevalence and significance of chronic obstructive pulmonary disease in subjects with acute coronary syndrome

Not Applicable

Completed

• Conditions: Chronic obstructive pulmonary disease, acute coronary syndrome; Respiratory; Chronic obstructive pulmonary disease; Acute ischaemic heart disease, unspecified

• Registration Number: ISRCTN05697808
• Lead Sponsor: Jämtland County Council (Sweden)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-05-04
• Last Update Posted: 27 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 350

Inclusion Criteria

1. All patients living in the county of Jämtland, Sweden, and hospitalised with a diagnosis of myocardial infarction or unstable angina will be assessed for inclusion
2. Östersund hospital is the only hospital in the county and all patients, terminal care excluded, with symptoms of a suspected acute coronary syndrome are referred for diagnostic evaluation
3. Study subjects are recruited in conjunction with the study Secondary preventive, nurse based, telephone follow-up for risk factor control after an acute coronary syndrome (http://www.isrctn.com/ISRCTN96595458/)

Exclusion Criteria

1. Dementia
2. Patients with severe disease
3. Subjects unable to perform adequate spirometry

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The prevalence of spirometry-verified COPD versus medical-record based COPD in subjects with ACS<br>2. The adjusted hazard ratio of spirometry-verified COPD for death, reinfarction and stroke in subjects with ACS. Adjustment for age, gender, renal function, C-reactive protein, Killip class, previous myocardial infarction (MI), atrial fibrillation, coronary intervention, secondary preventive medication, diabetes, and smoking history.

Secondary Outcome Measures

Name	Time	Method
In subjects with ACS, spirometry-verified COPD is an independent predictor of hospital admissions (due to coronary angiography, percutaneous coronary intervention, coronary artery bypass surgery, angina, heart failure) and length of hospital stay.