A Study on Intima Media Thickness (IMT) in Middle-aged Subjects

Completed

• Conditions: Atherosclerosis

• Registration Number: NCT00784264
• Lead Sponsor: AstraZeneca

Brief Summary

This is an observational study to measure the thickness of artery walls in the neck (intima media thickness IMT) by ultrasound examination in middle-aged subjects with central obesity. The purpose of this study is to obtain local data how common asymptomatic atherosclerosis is, and to investigate the association between Cardiovascular Disease risk factors and intima media thickness (IMT) in the Hong Kong population. Results from this study may enhance the public awareness of asymptomatic atherosclerosis and understand its role in the development of Cardiovascular Disease in Hong Kong.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2008-10-22
• Study First Submitted QC: 2008-10-31
• Study First Posted: 2008-11-02
• Study Completion: 2009-06
• Status Verified: 2010-01
• Last Update Submitted: 2010-01-11
• Last Update Posted: 2010-01-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Male or female aged 55 years or above.
• Waist circumference: male more than 90 cm; female more than 80 cm.

Exclusion Criteria

• Any known chronic diseases requiring long-term medication such as hypertension, diabetes and hyperlipidemia.
• Presence of known cardiovascular diseases including cerebro-vascular disease, coronary heart disease and peripheral artery disease.
• Presence of any active major diseases that may interfere the physical conditions and body weight of subjects during the study period, which include malignancy, infection, renal or liver function impairment, recent major surgery (within 3 months).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate the prevalence of asymptomatic atherosclerosis by measurement of intima media thickness (IMT) in middle-aged subjects with central obesity in Hong Kong,	during the one single study visit

Secondary Outcome Measures

Name	Time	Method
To examine the association between IMT value and cardiovascular disease (CVD) risk factors, and blood lipid and glucose profiles in middle-aged centrally obese subjects in Hong Kong.	During the one single study visit
IMT results to be compared with what being reported in the recent literature on normal Chinese population.	During the one single study visit

Trial Locations

Locations (1)

Research Site; 🇭🇰 Hong Kong, Hong Kong