Effects of using Colchicine for the prevention of inflammatory complications, arrhythmias and pain control in the postoperative period of cardiac surgery.

Not Applicable

• Conditions: Atrial Fibrillation; Pain; Pleural Effusion; Pericarditis; Other functional disturbances following cardiac surgery.

• Registration Number: RBR-5f426rx
• Lead Sponsor: niversidade de Santa Cruz do Sul

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-09-10
• Study Start: 2022-07-06
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients in post operative of cardiac surgery; both sexes; age 18 to 85 years.

Exclusion Criteria

Patients undergoing emergency cardiac surgery; presence of atrial fibrillation in the preoperative period; use of pacemakers; patients with chronic renal failure; patients undergoing treatment for endocarditis.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Colchicine did not alter the occurrence of post-pericardiotomy syndrome and had a small effect size (greater than 0.02) on pain control, assessed using the Visual Analog Pain Scale (VAS), which is an instrument self-report, consisting of colors and facial expressions in which the degree of pain varies from zero to ten, with zero meaning total absence of pain and ten, the level of maximum bearable pain.

Secondary Outcome Measures

Name	Time	Method
51% improvement in C-reactive protein indices in patients who used Colchicine in the postoperative period of cardiac surgery, evaluated through blood sample considering reference value less than 0.6 mg/dL for the presence of inflammation considering the present values in the post-intervention and in the immediate postoperative period.