Effects of Different Fresh Gas Flows on Carboxyhemoglobin Levels

Completed

• Conditions: Carboxyhemoglobinemia; Fresh Flow
• Interventions: Device: Radical-7 Pulse CO-Oximeter

• Registration Number: NCT04832256
• Lead Sponsor: Zonguldak Bulent Ecevit University

Brief Summary

To observe the effect of different fresh flows (1 L / min and 4 L / min) on the carboxyhemoglobin level non-invasively and continuous measurement and to determine the contribution of smoking to the intraoperative carbon monoxide accumulation.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-01
• Primary Completion: 2018-12-31
• Study Completion: 2019-06-01
• Study First Submitted: 2021-03-30
• Study First Submitted QC: 2021-04-02
• Study First Posted: 2021-04-05
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-01
• Last Update Posted: 2022-05-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• ASA I-II
• Undergo 2-4 hours of elective surgery

Exclusion Criteria

• Cardiovascular disease
• diabetes mellitus
• kidney, liver failure
• chronic obstructive pulmonary disease
• patients with opioid sensitivity
• morbidly obese
• personal or family history of malignant hyperthermia
• history of prolonged recovery from anesthesia
• alcohol addicted
• pregnant and breastfeeding women patients allergic to study drugs

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Low Flow Anesthesia	Radical-7 Pulse CO-Oximeter	administered 1 L/min fresh gas flow during general anesthesia
High Flow anesthesia	Radical-7 Pulse CO-Oximeter	administered 4 L/min fresh gas flow during general anesthesia

Primary Outcome Measures

Name	Time	Method
effects of different fresh gas flows on carboxyhemoglobin levels	during surgery	To observe the effect of different fresh flows (1 L / min and 4 L / min) on the carboxyhemoglobin level by non-invasive and continuous measurement.

Secondary Outcome Measures

Name	Time	Method
effects of smoking on carbon monoxide accumulation.	during surgery	to determine the contribution of smoking to intraoperative carbon monoxide accumulation.

Trial Locations

Locations (1)

Zonguldak Bülent Ecevit University Medicine Faculty; 🇹🇷 Zonguldak, Kozlu, Turkey