nderstanding chronic cough

Not Applicable

Completed

• Conditions: Chronic cough; Respiratory

• Registration Number: ISRCTN65122210
• Lead Sponsor: niversity Hospitals South Manchester NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04-07
• Last Update Posted: 27 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Healthy volunteers
1. Over 18 years old
2. Normal lung function
3. No current or past history of chronic cough or chronic respiratory illness
4. No current or past history of chronic pain, irritable bowel syndrome or chronic headaches
5. No current or past history of psychiatric illness

Asthmatics
1. Over 18 years old
2. Physician diagnosis of asthma
3. Objective evidence of bronchial hyper-reactivity (either positive bronchial provocation test or significant (>12%) reversibility in FEV1 following inhaled bronchodilator)
4. Stable asthma [forced expiratory volume in one second (FEV1) > 75% predicted, no acute exacerbations requiring oral corticosteroids within last 4 weeks]
5. Can safely omit long-acting bronchodilators (if taking)

Chronic Cough Patients
1. Over 18 years old
2. Chronic cough, defined as a cough lasting longer than 8 weeks despite investigation and/or treatment trials for cough variant asthma, post-nasal drip and gastro-oesophageal reflux disease
3. Normal chest x-ray
4. Normal lung function
5. Can safely omit long-acting bronchodilators (if taking)

Exclusion Criteria

All participants:
1. Recent upper respiratory tract infection (< 4weeks)
2. Pregnancy or breast-feeding
3. Use of agiotensin converting enzyme (ACE) inhibitors
4. Any centrally acting medication which could alter the sensitivity of the cough reflex
5. History of drug or alcohol abuse
6. Current smoker or ex-smoker with > 10 pack year smoking history

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of maximum cough responses between patient groups

Secondary Outcome Measures

Name	Time	Method
1. Comparison of cough threshold between patient groups<br>2. Comparison of urge-to-cough threshold between patient groups<br>3. Comparison of maximum cough responses and cough threshold in men and women