Shifting perspectives on postural instability in Parkinson's disease
Recruiting
- Conditions
- Parkinson's disease10028037
- Registration Number
- NL-OMON34771
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 64
Inclusion Criteria
Patients:
-Idiopathic Parkinson*s disease
-Hoehn and Yahr stages 1-2.5
-age between 18 and 70 years
Exclusion Criteria
- Cognitive impairment (MMSE < 24)
- Clinically relevant depression or anxiety disorders according to DSM-IV
- Visual impairment
- Vestibular impairment
- other disorders than Parkinson*s disease of the neuro-musculo-skeletal system
- inability to perform the set-shift task seated
- any inability to cooperate with the assessments and to give written informed consent
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The relationship between switch costs, defined as the relative difference in<br /><br>reaction time between response to non-switch trials and response to<br /><br>cognitive-motor switch trials (experimental task 1) and stepping reaction<br /><br>times to perturbations (experimental task 2).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Experimental task 1:<br /><br>o Switch costs of the cognitive shift only condition and of the motor shift<br /><br>only condition<br /><br>o Error rates<br /><br>Experimental task 2:<br /><br>o Excursion of centre of mass<br /><br>o Amplitude of the step </p><br>