Effects of Dietary Fiber on Insulin Sensitivity
Not Applicable
- Conditions
- Focus of the Study is Insulin Sensitivity
- Interventions
- Dietary Supplement: Dietary Fiber
- Registration Number
- NCT01521806
- Lead Sponsor
- Ingredion Incorporated
- Brief Summary
This study will examine the effects of a dietary fiber on insulin sensitivity in overweight and obese women. The fiber will be added to snack foods and women will consume the foods for four weeks. In one four-week period, 15 g of fiber will be added, and 30 g will added in another period. In a third period, no fiber will be added to the snack foods. Insulin senstivity will be measured at the end of each treatment period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 40
Inclusion Criteria
- Impaired fasting glucose
- Overweight and obese
Exclusion Criteria
- Diabetes, Presence of chronic diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Low dose Dietary Fiber 15 g of fiber per day will be added to snack foods High dose Dietary Fiber 30 g of fiber per day will be added to snack foods No fiber Dietary Fiber Snack foods without fiber will be given
- Primary Outcome Measures
Name Time Method Insulin sensitivity 5-hr test, performed 3 times within a 20-week period A frequently sampled intravenous blood glucose tolerance test will be performed.
- Secondary Outcome Measures
Name Time Method Mitocondrial function 3 times, with a 20-week period A muscle biospy will be taken to assess mitochondrial function
Meal tolerance test 3 times, within a 20-week period A high-fat meal will be given and blood will be drawn over a three-hr period
Trial Locations
- Locations (1)
Clinical Research Unit
🇺🇸Birmingham, Alabama, United States